He recognized the myriad pressures on a suicidal mind—substance abuse, genetic predisposition to mental illness, poverty—but identified three factors present in all of those most at risk: a genuine belief, however irrational, that they have become a burden to those around them; a sense of isolation; and the ability, which goes against our hard-wired instincts of self-preservation, to hurt oneself (this combines access to a means of suicide with what Joiner describes as a “learned fearlessness”; Covington calls it an “acquired capability”). 

https://www.theatlantic.com/health/archive/2017/08/zero-suicide-strategy/535587/